What is the Entourage Effect in Cannabis?

What is The Entourage Effect in Cannabis?

What is The Entourage Effect in Cannabis?
The Entourage Effect almost sounds like a TV series. But what is the Entourage Effect in Cannabis? We have heard of cannabinoids, THC and CBD and sometimes even Terpenes and Flavonoids, but there are far more to it.

There are also THCa, CBG, CBN, CBC and THCc in play to name some more. Mainstream publicity focus mostly on THC and CBD, but there are many cannabinoids and terpenoids that all come from the same plant with loads of medicinal properties.

What is the Entourage Effect in Cannabis?

The Entourage effect means the combined effect of all cannabinoids, terpenes and other chemical compounds in the marijuana plant.

The effect produced by the compounds working together is far greater than just one or two singled-out compounds. Entourage literally means surrounding and supporting one another.

What make Cannabis so special are all the hundreds of chemicals it contains. As cannabinoids move through the human body, they interact with the body as well as themselves.

They sometimes change their composition and turn into another cannabinoid. On bio-chemistry level there is still much to learn and understand from how it all works.

What scientists believe is that the synergy that characterizes the cannabinoid’s relationship with one- another empowers the entourage effect.

How can the Entourage Effect be used to favor medical cannabis?

It seems that when experts come to ask what is the Entourage in Cannabis,  they conclude that it is the basis on which medical cannabis will build in future. Together they are stronger than one. A study in 1981 discovered that whole plant extracts produce 330% more activity than THC alone.

Cannabis has synergist and inhibitor compounds. Both cannabinoids and terpenes are responsible for that. As an example, CBD cannabinoids counter the psychoactive effect of THC while the positive effects are boosted.

Terpenes also play a role in the entourage effect. Terpenes are compounds that contribute to the flavor and scent of marijuana.

Terpenes have the ability to alter how cannabinoids bind to the receptors and thus also alter the effect. Terpenes and cannabinoids share a chemical precursor that underlines their chemical similarity.

Terpenes also contribute to pain relief and sedation as well as other effects. They are also anti-bacterial, anti-inflammatory, anti-depressant and combat anxiety.

Why is the Entourage Effect only been recognized now?

Cannabidiol (CBD) was the first to pave the road for the acceptance of cannabis for medicinal purposes. CBD has no psychoactive effects and when positive results streamed in when used for therapeutic treatment, scientist also started to look at the benefits of THC.


As it is evident that Cannabinoids treat conditions like depression, insomnia, anxiety, dementia and other, it is also concluded that terpenes enhance the benefits.

Terpenes like limonene and linalool better the effects of CBD. The same two terpenes combined with pinene, enhance the positive effects of THC used for Alzheimer and dementia patients.

Sometimes a disease can’t be treated with one cannabinoid only. The synergy produced by the entourage effect is important to treat conditions where one cannabinoid alone would not have the same effect. The range of the effect of phyto-cannabinoids is so big, that only further investigation would reveal it all.